Clinical Trial

The effectiveness of DENNKUR in the treatment of generalized gingivitis*

2024, Department of Periodontology, Belarusian State Medical University

Complex treatment was carried out on 22 patients. aged 18-35 years with chronic generalized simple marginal gingivitis of moderate severity with the inclusion of the drug DENNKUR as additional therapy 1 tablet 2 times a day for 5 days.

Results:
Decreased prevalence of gingivitis 2 times, reduction in the intensity of gum inflammation by 1.8 times, improvement in the peripheral circulation index by 2 times.

*Scientific and practical journal "DENTIST 2-2025", pp. 63-64

Efficacy of DENNKUR in regulating gum inflammation and oral hygiene parameters in adults*

Non-randomized prospective single-arm intervention study Mumbai, India by
Dr Vaibhav Kumar [MDS (PHD), FRSPH, FICD, FPFA]

July-October 2025 (90 days)
Clinical observations of 120 patients aged 18-40 years in India began from July 7, 2025, to October 19, 2025. Each patient was assessed with a modified gingival index (MGI), reflecting varying degrees of gingival recession, bleeding, and halitosis at the initial examination.

Throughout the study period, all participants continued their normal oral hygiene regimen using standard fluoride toothpaste and did not use any other oral hygiene products or other corrective clinical treatments, except for Dennkur, taken as lozenges, twice daily.

Results: The observation showed a significant improvement in the modified gingival index, a decrease in plaque accumulation, a decrease in bleeding on probing, and a decrease in bad breath (halitosis).

Comparative evaluation of Curcumin and Chlorhexidine in the treatment of gingivitis*

Double-blind, randomized, controlled clinical trial.
Venue: Department of Periodontology, Oxford Dental College, Bangalore, India. 2017.

A study was conducted among 150 patients, aged 20 to 30 years with chronic gingivitis to compare the efficacy of a 0.1% curcumin mouthwash and a 0.2% chlorhexidine solution. The study duration was 28 days.

Results: A curcumin - containing mouthwash demonstrated effectiveness in combating plaque and gingivitis. The effect was comparable to that of chlorhexidine solution.

* Journal of Indian Society of Periodontology 21(2):p 132-137, Mar-Apr 2017
(Journal of Indian Society of Periodontology No.21(2): pp. 132-137, March-April 2017)

Efficacy of Curcumin in the treatment of chronic periodontitis*

Venue: Department of Periodontology, Narsinhbhai Dental College Patel, North Gujarat, India, 2014

A study was conducted among 25 patients, aged 21 to 45 years with a diagnosis of chronic periodontitis were randomized. The study group received 1% curcumin gel along with scaling and root planing, while the control group received scaling and root planing alone, followed by microbiological testing of samples taken at baseline, 1, 3, and 6 months.

Results: Topical application of curcumin gel was more effective in inhibiting the growth of oral bacteria when used as an adjunct to SRP in the treatment of chronic periodontitis.

* Journal of Clinical and Diagnostic Research. 2014 Dec, Vol-8(12): ZC65-ZC69
(Journal of Clinical and Diagnostic Research. December 2014, Vol. 8(12): ZC65-ZC69)

Antibacterial Action Of Curcumin Against Streptococcus mutans*

Venue: Department of Periodontology, Narsinhbhai Dental College Patel, North Gujarat, India, 2014
Archives of Oral Biology Volume 149, May 2023, 105655 - International peer-reviewed journal "Archives of Oral Biology", May 2023.

Setting: Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China

Design: The antibacterial activity of curcumin was assessed by measuring the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC).

Results: Curcumin showed significant inhibitory effect on the growth of bacteria such as Streptococcus mutans, which are the main causative agents of dental caries.

Conclusion: Curcumin can be used as an alternative treatment for dental caries with a wide range of clinical applications.